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Product Details
22026-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | View 3 publications 3 publications |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Dog, Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
NPHP3 Fusion Protein Ag16888 (1-131 aa encoded by BC068082) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.51 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MGTASSLVS PAGGEVIEDT YGAGGGEACE IPVEVKPKAR LLRNSFRRGA GAAAGAGPGS LPRGVGAGGL LGASFKSTGS SVPELEYAAA EYERLRKEYE IFRVSKNQEL LSMGRREAKL DTENKRLRAE LQ (1-131 aa encoded by BC068082)
Target Information
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cilia and flagella associated protein 31; Meckel syndrome, type 7; Nephrocystin-3; nephronophthisis 3 (adolescent)
Gene Aliases: 3632410F03Rik; AI550417; C230078J01; CFAP31; D330020E01Rik; KIAA2000; MKS7; NPH3; NPHP3; pcy; RGD1563856; RHPD; RHPD1; SLSN3
UniProt ID: (Human) Q7Z494, (Mouse) Q7TNH6
Entrez Gene ID: (Dog) 100856544, (Human) 27031, (Mouse) 74025, (Rat) 363126
kidney development
heart looping
atrial septum development
lipid metabolic process
establishment or maintenance of cell polarity
determination of left/right symmetry
Wnt signaling pathway
extracellular matrix organization
lung development
regulation of cAMP metabolic process
determination of pancreatic left/right asymmetry
photoreceptor cell maintenance
maintenance of organ identity
convergent extension involved in gastrulation
cilium morphogenesis
kidney morphogenesis
determination of intestine left/right asymmetry
determination of stomach left/right asymmetry
determination of liver left/right asymmetry
ureter development
negative regulation of canonical Wnt signaling pathway
epithelial cilium movement involved in determination of left/right asymmetry
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of planar cell polarity pathway involved in neural tube closure
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