Proteintech

NPLOC4 Polyclonal Antibody

NPLOC4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NPLOC4 Antibody (11638-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 11638-1-AP ( NPLOC4 Antibody) at dilution of 1:50 (under 40x lens).

NPLOC4 Antibody in Immunoprecipitation (IP)

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Product Details

11638-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NPLOC4 Fusion Protein Ag2219 (261-608 aa encoded by BC025930)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DIPLGIRAE VAAIYEPPQI GTQNSLELLE DPKAEVVDEI AAKLGLRKVG WIFTDLVSED TRKGTVRYSR NKDTYFLSSE ECITAGDFQN KHPNMCRLSP DGHFGSKFVT AVATGGPDNQ VHFEGYQVSN QCMALVRDEC LLPCKDAPEL GYAKESSSEQ YVPDVFYKDV DKFGNEITQL ARPLPVEYLI IDITTTFPKD PVYTFSISQN PFPIENRDVL GETQDFHSLA TYLSQNTSSV FLDTISDFHL LLFLVTNEVM PLQDSISLLL EAVRTRNEEL AQTWKRSEQW ATIEQLCSTV GGQLPGLHEY GAVGGSTHTA TAAMWACQHC TFMNQPGTGH CEMCSLPRT (261-608 aa encoded by BC025930)

Target Information

NPLOC4 gene ontology annotations related to this gene include ubiquitin-dependent protein catabolic process.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

1,25(OH)₂ D₃ induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.

Cellular signalling

Erzurumlu Y,Aydogdu E,Dogan HK,Catakli D,Muhammed MT,Buyuksandic B

Wed Mar 01 00:00:00 UTC 2023

Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.

Cellular signalling

Erzurumlu Y,Muhammed MT

Fri Sep 01 00:00:00 UTC 2023

Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.

Steroids

Erzurumlu Y,Dogan HK,Cataklı D

Sat Jul 01 00:00:00 UTC 2023

Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.

Molecular biology reports

Erzurumlu Y,Dogan HK,Catakli D

Wed Feb 01 00:00:00 UTC 2023

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

Science (New York, N.Y.)

Gwon Y,Maxwell BA,Kolaitis RM,Zhang P,Kim HJ,Taylor JP

Fri Jun 25 00:00:00 UTC 2021

The p97-UBXN1 complex regulates aggresome formation.

Journal of cell science

Mukkavalli S,Klickstein JA,Ortiz B,Juo P,Raman M

Thu Apr 01 00:00:00 UTC 2021

The p97-UBXN1 complex regulates aggresome formation.

Journal of cell science

Mukkavalli S,Klickstein JA,Ortiz B,Juo P,Raman M

Thu Apr 01 00:00:00 UTC 2021

Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.

Virus research

Yan J,Wang M,Wang M,Dun Y,Zhu L,Yi Z,Zhang S

Thu Jul 02 00:00:00 UTC 2020

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.

Molecular and cellular biology

Ganji R,Mukkavalli S,Somanji F,Raman M

Sun Jul 01 00:00:00 UTC 2018

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.

Molecular and cellular biology

Ganji R,Mukkavalli S,Somanji F,Raman M

Sun Jul 01 00:00:00 UTC 2018

Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.

The Journal of biological chemistry

Wang T,Xu W,Qin M,Yang Y,Bao P,Shen F,Zhang Z,Xu J

Fri Jul 01 00:00:00 UTC 2016

Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.

The Journal of biological chemistry

Wang T,Xu W,Qin M,Yang Y,Bao P,Shen F,Zhang Z,Xu J

Fri Jul 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: FLJ20657; homolog of yeast nuclear protein localization 4; NPLOC4 ubiquitin recognition factor; nuclear protein localization 4 homolog; Nuclear protein localization protein 4 homolog; Protein NPL4

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Gene Aliases: AK129375; KIAA1499; mKIAA1499; NPL4; NPLOC4

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UniProt ID: (Human) Q8TAT6, (Mouse) B1ATY4, (Rat) Q9ES54

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Entrez Gene ID: (Human) 55666, (Mouse) 217365, (Rat) 140639

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Function(s)

protein binding zinc ion binding ubiquitin protein ligase binding ubiquitin binding protein complex binding K48-linked polyubiquitin binding metal ion binding K63-linked polyubiquitin binding

Process(es)

ubiquitin-dependent protein catabolic process Golgi organization retrograde protein transport, ER to cytosol membrane fusion proteasome-mediated ubiquitin-dependent protein catabolic process ER-associated ubiquitin-dependent protein catabolic process error-free translesion synthesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NPLOC4 Polyclonal Antibody

NPLOC4 Antibody (11638-1-AP) in IHC (P)

Product Details

11638-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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