The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.
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Protein Aliases: ANF; ANP; Atrial natriuretic factor; Atrial natriuretic peptide; atriopeptin; Atriopeptin I; Atriopeptin II; Atriopeptin-1; Atriopeptin-2; Auriculin-A; Auriculin-B; Cardiodilatin; Cardiodilatin-related peptide; cardionatrin; CDD; CDD-ANF; CDP; natriuretic peptide precursor A variant 1; natriuretic peptide precursor A variant NPPA-M1; natriuretic peptide precursor A variant NPPA-M2; natriuretic peptide precursor A variant NPPA-M3; natriuretic peptide precursor type A; Natriuretic peptides A; Prepronatriodilatin; Pronatriodilatin; urodilatin
Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; NPPA; PND