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Proteintech
NPPA Polyclonal Antibody
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Product Details
27426-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NPPA Fusion Protein Ag26692 (26-153 aa encoded by BC005893)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NPMYNAVSN ADLMDFKNLL DHLEEKMPLE DEVVPPQVLS EPNEEAGAAL SPLPEVPPWT GEVSPAQRDG GALGRGPWDS SDRSALLKSK LRALLTAPRS LRRSSCFGGR MDRIGAQSGL GCNSFRYRR (26-153 aa encoded by BC005893)
Target Information
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: atrial natriuretic factor; Atrial natriuretic factor prohormone; atrial natriuretic peptide; Atrial natriuretic peptide prohormone; Atriopeptigen; atriopeptin; Cardiodilatin; cardiodilatin-related peptide; cardionatrin; CDD; natriuretic peptide precursor A; Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd); natriuretic peptide precursor A variant NPPA-M1; natriuretic peptide precursor A variant NPPA-M2; natriuretic peptide precursor A variant NPPA-M3; natriuretic peptide precursor type A; Natriuretic peptides A; preproANF; preproANP; preprocardiodilatin-atrial natriuretic factor; preproCDD-ANF; prepronatiodilatin (PND); prepronatriodilatin; proANF; proANP; Pronatriodilatin; urodilatin
Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; NPPA; PND; RATANF
UniProt ID: (Human) P01160, (Rat) P01161, (Mouse) P05125
Entrez Gene ID: (Human) 4878, (Rat) 24602, (Mouse) 230899
response to hypoxia
system process
negative regulation of systemic arterial blood pressure
cardiac conduction system development
aortic valve morphogenesis
cGMP biosynthetic process
protein folding
receptor guanylyl cyclase signaling pathway
neuropeptide signaling pathway
female pregnancy
regulation of blood pressure
positive regulation of heart rate
positive regulation of cGMP-mediated signaling
cardiac muscle hypertrophy in response to stress
cGMP-mediated signaling
negative regulation of cell growth
response to insulin
response to muscle stretch
sodium ion export from cell
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
regulation of vascular permeability
negative regulation of JUN kinase activity
negative regulation of blood pressure
regulation of atrial cardiac muscle cell membrane repolarization
positive regulation of cardiac muscle contraction
cell growth involved in cardiac muscle cell development
cellular response to hydrogen peroxide
cellular response to mechanical stimulus
negative regulation of canonical Wnt signaling pathway
regulation of blood vessel diameter
synaptic signaling via neuropeptide
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of potassium ion export across plasma membrane
negative regulation of collecting lymphatic vessel constriction
cellular response to angiotensin
response to 3-methylcholanthrene
heart development
regulation of body fluid levels
regulation of blood vessel size
multicellular organismal water homeostasis
regulation of high voltage-gated calcium channel activity
positive regulation of delayed rectifier potassium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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