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Invitrogen
NPR2 Polyclonal Antibody
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FIGURE: 1 / 2
NPR2 Antibody (PA5-99836) in IHC (P)
Immunohistochemistry analysis of NPR2 in rat brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with NPR2 polyclonal antibody (Product # PA5-99836) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-99836
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NPR2(Accession P20594), corresponding to amino acid residues S647-L697.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NPR2.
Target Information
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; guanylyl cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; Nppb receptor; NPR-B
Gene Aliases: AMD1; AMDM; ANPb; ANPRB; cn; ECDM; GC-B; GC-B2; GC-B3; GCB; GUC2B; GUCY2B; mNPR-B; NPR-B; NPR2; NPRB; NPRBi; pwe; SNSK
UniProt ID: (Human) P20594, (Rat) P16067, (Mouse) Q6VVW5
Entrez Gene ID: (Human) 4882, (Rat) 116564, (Mouse) 230103
nucleotide binding
guanylate cyclase activity
protein kinase activity
protein binding
ATP binding
GTP binding
lyase activity
phosphorus-oxygen lyase activity
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
transferase activity, transferring phosphorus-containing groups
guanylate cyclase
MAPK cascade
ossification
ovarian follicle development
cumulus cell differentiation
blood vessel development
vasculogenesis
lymph vessel development
endochondral ossification
startle response
blood vessel remodeling
chondrocyte differentiation
growth plate cartilage development
cGMP biosynthetic process
vacuole organization
receptor guanylyl cyclase signaling pathway
epidermal growth factor receptor signaling pathway
chemical synaptic transmission
germ cell development
spermatogenesis
single fertilization
axonogenesis
sensory perception of sound
blood circulation
regulation of blood pressure
cyclic nucleotide biosynthetic process
response to wounding
response to hormone
neuronal action potential
vestibulocochlear nerve development
vestibulocochlear nerve maturation
nerve development
female genitalia development
response to luteinizing hormone
limb morphogenesis
genitalia morphogenesis
multicellular organism growth
gastric emptying
intracellular signal transduction
chondrocyte proliferation
post-anal tail morphogenesis
cGMP metabolic process
digestive tract morphogenesis
digestive tract development
oocyte development
collateral sprouting
smooth muscle tissue development
white fat cell differentiation
cartilage development
chromosome organization
meiotic cell cycle
neuron apoptotic process
negative regulation of meiotic cell cycle
limb development
bone development
axonogenesis involved in innervation
activation of meiosis involved in egg activation
vascular wound healing
c-di-GMP signaling
cellular response to cGMP
response to fibroblast growth factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
execution phase of apoptosis
bone growth
negative regulation of oocyte maturation
cellular response to peptide
response to salt
meiotic cell cycle process involved in oocyte maturation
protein phosphorylation
signal transduction
single organism reproductive process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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