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Product Details
PA5-67690
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human NPRL2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2691687
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2810446G01Rik; G21 protein; GATOR1 complex protein NPRL2; Gene 21 protein; homologous to yeast nitrogen permease (candidate tumor suppressor); nitrogen permase homolog; Nitrogen permease regulator 2-like protein; NPR 2L; NPR L2; NPR like 2; NPR2 like; NPR2-like protein; NPRL 2; Tumor suppressor candidate 4; TUSC 4; TUSC 4 protein; TUSC4 protein
Gene Aliases: 2810446G01Rik; G21; NPR2; NPR2L; NPRL2; TUSC4
UniProt ID: (Human) Q8WTW4, (Mouse) Q9WUE4
Entrez Gene ID: (Human) 10641, (Mouse) 56032, (Rat) 363138
Performance Guarantee
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