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Product Details
OSN00016W-150UL
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:300-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:300-1:3,000 | - |
Immunohistochemistry (Frozen) (IHC (F)) |
1:300-1:3,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rabbit, Rat, Xenopus |
Host/Isotype |
Goat / Ig |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide from aa region 20-70 of mouse NPY (Neuropeptide Y) conjugated to an immunogenic carrier protein was used as the immunogen |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Storage buffer |
whole serum |
Contains |
no preservative |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in many other species including human, rat, zebrafish and xenopus.
Specificity of this antibody: NPY.
Target Information
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; Neuropeptide Y; Neuropeptide-Y; NPY; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y; pro-neuropeptide Y-like
Gene Aliases: 0710005A05Rik; NPY; NPY02; PYY4; RATNPY; RATNPY02
UniProt ID: (Human) P01303, (Mouse) P57774, (Rat) P07808
Entrez Gene ID: (Rat) 100912228, (Human) 4852, (Rabbit) 100301542, (Mouse) 109648, (Rat) 24604
Molecular Function:
intercellular signal molecule
neuropeptide signaling pathway
cell-cell signaling
feeding behavior
regulation of appetite
calcium ion transport
movement of cell or subcellular component
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
digestion
behavior
blood circulation
regulation of blood pressure
cell proliferation
adult feeding behavior
central nervous system neuron development
cerebral cortex development
neuron projection development
positive regulation of appetite
negative regulation of blood pressure
sensory perception of taste
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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