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NPY Polyclonal Antibody
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FIGURE: 1 / 7
NPY Antibody (OSN00111W-100UL) in IHC (P)
IHC-P on paraffin sections of rat olfactory bulbs. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela ... View More
Product Details
OSN00111W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 20-60 of mouse NPY conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in many other species including human, rat, zebrafish and xenopus.
Specificity of this antibody: NPY.
Target Information
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neuropeptide-Y; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y; pro-neuropeptide Y-like; unnamed protein product
Gene Aliases: 0710005A05Rik; NPY; NPY02; PYY4; RATNPY; RATNPY02
UniProt ID: (Human) P01303, (Mouse) P57774, (Rat) P07808
Entrez Gene ID: (Rat) 100912228, (Human) 4852, (Mouse) 109648, (Rat) 24604
neuropeptide signaling pathway
cell-cell signaling
feeding behavior
regulation of appetite
response to yeast
negative regulation of acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
regulation of blood pressure
positive regulation of cell proliferation
adult feeding behavior
positive regulation of cell-substrate adhesion
antibacterial humoral response
antifungal humoral response
central nervous system neuron development
cerebral cortex development
neuron projection development
positive regulation of appetite
regulation of nerve growth factor production
monocyte activation
innate immune response
negative regulation of blood pressure
positive regulation of dopamine metabolic process
short-day photoperiodism
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
intestinal epithelial cell differentiation
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of ERK1 and ERK2 cascade
regulation of presynaptic cytosolic calcium ion concentration
synaptic signaling via neuropeptide
positive regulation of eating behavior
positive regulation of nitric oxide metabolic process
regulation of synaptic vesicle exocytosis
sensory perception of taste
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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