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Product Details
PA5-28737
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Human NR1D1
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546213
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, HepG2.
Predicted reactivity: Mouse (100%), Rat (100%), Sheep (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BD73; EAR-1; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; Rev-erba; Rev-erbA-alpha; Rev-ErbAalpha; Reverbaalpha; V-erbA-related protein 1
Gene Aliases: ear-1; EAR1; HREV; NR1D1; THRA1; THRAL
UniProt ID: (Human) P20393
Entrez Gene ID: (Human) 9572
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription corepressor binding
steroid hormone receptor activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
heme binding
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glycogen biosynthetic process
transcription initiation from RNA polymerase II promoter
circadian rhythm
proteasomal protein catabolic process
negative regulation of receptor biosynthetic process
regulation of lipid metabolic process
cell differentiation
intracellular receptor signaling pathway
circadian regulation of gene expression
negative regulation of toll-like receptor 4 signaling pathway
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
steroid hormone mediated signaling pathway
response to leptin
regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
circadian temperature homeostasis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of type B pancreatic cell proliferation
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
regulation of cholesterol homeostasis
positive regulation of cholesterol homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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