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Invitrogen
NR1D2 Polyclonal Antibody
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Product Details
PA5-32948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Chicken,
Horse,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from internal region of human NR1D2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Bat, Panda, Horse, Rabbit, Turkey, Chicken (100%); Elephant, Platypus (94%); Opossum, Xenopus (81%).
For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAR-1R; EAR4; HZF2; NR1D2; Nuclear receptor subfamily 1 group D member 2; Nuclear receptor subfamily 1 group D member 2-like protein; Orphan nuclear hormone receptor BD73; orphan nuclear receptor HZF-2; Orphan nuclear receptor RVR; orphan receptor; Rev-erb alpha-related receptor; Rev-erb beta; Rev-erb-beta; Rev-erb-Beta2; Rev-erba beta; rev-erba-alpha-related receptor; Rev-ErbA-beta; Rev-erbabeta; REV-ERBb; RVR; unnamed protein product; V-erbA-related protein 1-related
Gene Aliases: BD73; EAR-1R; HZF-2; NR1D2; Rev-erb; REV-ERBB; REVERBB; REVERBbeta; RVR
UniProt ID: (Human) Q14995, (Mouse) Q60674, (Rat) Q63504
Entrez Gene ID: (Human) 9975, (Rabbit) 100349421, (Horse) 100060122, (Dog) 485643, (Bovine) 532076, (Chicken) 396125, (Mouse) 353187, (Rat) 259241
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
core promoter sequence-specific DNA binding
steroid hormone receptor activity
thyroid hormone receptor activity
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
hormone-mediated signaling pathway
regulation of lipid metabolic process
cell differentiation
intracellular receptor signaling pathway
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
circadian behavior
regulation of inflammatory response
negative regulation of inflammatory response
lipid homeostasis
energy homeostasis
regulation of skeletal muscle cell differentiation
transcription, DNA-templated
steroid hormone mediated signaling pathway
regulation of energy homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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