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Product Details
13658-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
NR2C1 Fusion Protein Ag4554 (118-467 aa encoded by BC040141) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.14 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: DKASGRHYG AVTCEGCKGF FKRSIRKNLV YSCRGSKDCI INKHHRNRCQ YCRLQRCIAF GMKQDSVQCE RKPIEVSREK SSNCAASTEK IYIRKDLRSP LTATPTFVTD SESTRSTGLL DSGMFMNIHP SGVKTESAVL MTSDKAESCQ GDLSTLANVV TSLANLGKTK DLSQNSNEMS MIESLSNDDT SLCEFQEMQT NGDVSRAFDT LAKALNPGES TACQSSVAGM EGSVHLITGD SSINYTEKEG PLLSDSHVAF RLTMPSPMPE YLNVHYIGES ASRLLFLSMH WALSIPSFQA LGQENSISLV KAYWNELFTL GLAQCWQVMN VATILATFVN CLHNSLQQAE G (118-467 aa encoded by BC040141)
Target Information
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80-3 cNDA; early embryonic nuclear receptor; mTR2; nr2c1; Nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group C isoform; nuclear receptor subfamily 2, group C, member 1; nuclear receptor subfamily 2, group H, member 1; Orphan nuclear receptor TR2; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Testicular receptor 2; TR2 nuclear hormone receptor
Gene Aliases: 4831444H07Rik; 80.3; Eenr; NR2C1; Psg4; TR2; TR2-11
UniProt ID: (Human) P13056, (Mouse) Q505F1, (Rat) Q8VIJ4
Entrez Gene ID: (Human) 7181, (Mouse) 22025, (Rat) 252924
Molecular Function:
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
steroid hormone mediated signaling pathway
positive regulation of retinoic acid receptor signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
receptor activity
protein binding
zinc ion binding
protein homodimerization activity
histone deacetylase binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
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