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Product Details
24573-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
NR2F1 Fusion Protein Ag0118 (178-421 aa encoded by BC004154) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: PLNGHCYLS GYISLLLRAE PYPTSRYGSQ CMQPNNIMGI ENICELAARL LFSAVEWARN IPFFPDLQIT DQVSLLRLTW SELFVLNAAQ CSMPLHVAPL LAAAGLHASP MSADRVVAFM DHIRIFQEQV EKLKALHVDS AEYSCLKAIV LFTSDACGLS DAAHIESLQE KSQCALEEYV RSQYPNQPSR FGKLLLRLPS LRTVSSSVIE QLFFVRLVGK TPIETLIRDM LLSGSSFNWP YMSIQ (178-421 aa encoded by BC004154)
Target Information
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 3; chicken ovalbumin upstream promoter-transcription factor I; COUP transcription factor 1; COUP transcription factor I; COUP-TF I; COUP-TF1; EAR-3; Nuclear receptor subfamily 2 group F member 1; nuclear receptor subfamily 2, group F, member 1; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3); V-erbA-related protein 3
Gene Aliases: BBOAS; BBSOAS; COUP-TF1; COUP-TFI; COUPTFA; EAR-3; EAR3; ERBAL3; NR2F1; NR2F2; SVP44; TCFCOUP1; TFCOUP1
UniProt ID: (Human) P10589, (Mouse) Q60632
Entrez Gene ID: (Human) 7025, (Rat) 81808, (Mouse) 13865
Molecular Function:
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
signal transduction
intracellular receptor signaling pathway
steroid hormone mediated signaling pathway
neuron migration
transcription, DNA-templated
nervous system development
positive regulation of receptor biosynthetic process
negative regulation of neuron projection development
cerebral cortex regionalization
forebrain development
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
retinoic acid-responsive element binding
DNA binding
metal ion binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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