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Proteintech
NR3C2 Polyclonal Antibody
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Product Details
21854-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NR3C2 Fusion Protein Ag16410 (1-350 aa encoded by BC111758)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody, specifically reacts with the 107 kDa MCR protein.
Immunogen sequence: METKGYHSL PEGLDMERRW GQVSQAVERS SLGPTERTDE NNYMEIVNVS CVSGAIPNNS TQGSSKEKQE LLPCLQQDNN RPGILTSDIK TELESKELSA TVAESMGLYM DSVRDADYSY EQQNQQGSMS PAKIYQNVEQ LVKFYKGNGH RPSTLSCVNT PLRSFMSDSG SSVNGGVMRA IVKSPIMCHE KSPSVCSPLN MTSSVCSPAG INSVSSTTAS FGSFPVHSPI TQGTPLTCSP NVENRGSRSH SPAHASNVGS PLSSPLSSMK SSISSPPSHC SVKSPVSSPN NVTLRSSVSS PANINNSRCS VSSPSNTNNR STLSSPAAST VGSICSPVNN AFSYTASGTS A (1-350 aa encoded by BC111758)
Target Information
Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor (MR) and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR. The corresponding gene for the mineralocorticoid receptor is NR3C2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aldosterone receptor; Mineralocorticoid receptor; Mineralocorticoid receptor (aldosterone receptor); mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; MR; Nuclear receptor subfamily 3 group C member 2; unnamed protein product
Gene Aliases: MCR; MLR; MR; NR3C2; NR3C2VIT
UniProt ID: (Human) P08235, (Rat) P22199
Entrez Gene ID: (Human) 4306, (Mouse) 110784, (Rat) 25672
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
zinc ion binding
lipid binding
TBP-class protein binding
estrogen response element binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
double-stranded DNA binding
mineralocorticoid receptor activity
hormone binding
protein homodimerization activity
protein heterodimerization activity
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cellular sodium ion homeostasis
excretion
mineralocorticoid receptor signaling pathway
regulation of cell proliferation
steroid hormone mediated signaling pathway
signal transduction
intracellular steroid hormone receptor signaling pathway
cellular response to hormone stimulus
response to lipid
positive regulation of NIK/NF-kappaB signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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