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Invitrogen
NR5A2 Polyclonal Antibody
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Product Details
PA5-73018
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Horse,
Guinea pig,
Hamster,
Human,
Marsupial,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rhesus monkey,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 140-190 from human NR5A2.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Sequence homology: Orangutan, Chimpanzee, New World Monkey, Panda, Great Ape, Mole Rat, White cheeked gibbon, Platypus, Zebra finch, Catfish, Frog, Carolina anole (all 100%).
Target Information
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; Fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTF; FTF/LRH-1; FTF; similar to nuclear hormone receptor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; FTZ-F1 homolog; fushi tarazu; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; Liver receptor homolog 1; liver receptor homolog-1; LRH-1; mFTF; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2; nuclear receptor; similar to FTZ-F1; OR2.0; orphan nuclear receptor; steroidogenic factor 1; steroidogenic factor 2; unnamed protein product; zFF1
Gene Aliases: AU020803; B1F; B1F2; CPF; D1Ertd308e; ff1a; FTF; ftz; FTZ-F1; FTZ-F1beta; ftzf1; hB1F-2; I79_021747; LRH-1; LRH1; NR5A2; SF-2; sf1; UF2-H3B; zFF1; zFF1A; zFF1B
UniProt ID: (Chicken) O42101, (Human) O00482, (Mouse) P45448, (Rat) Q9QWM1, (Zebrafish) Q90YL6
transcription regulatory region sequence-specific DNA binding
chromatin binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
zinc ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
phospholipid binding
lipid binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
steroid hormone receptor activity
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
hormone-mediated signaling pathway
tissue development
intracellular receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
primary ovarian follicle growth
inner cell mass cell differentiation
positive regulation of T cell anergy
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
bile acid metabolic process
embryo development ending in birth or egg hatching
neurogenesis
exocrine pancreas development
positive regulation of glucocorticoid biosynthetic process
negative regulation of chondrocyte differentiation
somatic stem cell population maintenance
embryonic cleavage
positive regulation of T cell proliferation
regulation of cell proliferation
homeostatic process
cholesterol homeostasis
positive regulation of viral genome replication
negative regulation of inflammatory response
positive regulation of T cell activation
cartilage development
Sertoli cell development
pancreas morphogenesis
acinar cell differentiation
calcineurin-mediated signaling
morula formation
zygotic genome activation
cellular response to leukemia inhibitory factor
positive regulation of stem cell differentiation
positive regulation of tendon cell differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
epithelial cell differentiation
steroid hormone mediated signaling pathway
liver development
digestive tract development
hepatoblast differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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