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NRAS Antibody (18296-1-AP150UL) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human malignant melanoma tissue slide using (Product # 18296-1-AP150UL) (NRAS-Specific antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
18296-1-AP150UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
NRAS (GTPase NRas) is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase NRas; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; RAS; RASN; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
Gene Aliases: ALPS4; CMNS; HRAS1; N-ras; NCMS; NRAS; NRAS1; NS6
UniProt ID: (Human) P01111, (Rat) Q04970
Entrez Gene ID: (Human) 4893, (Rat) 24605
MAPK cascade
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
leukocyte migration
establishment of protein localization to Golgi
small GTPase mediated signal transduction
biological_process
positive regulation of cell proliferation
visual learning
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
negative regulation of skeletal muscle tissue development
striated muscle cell differentiation
epithelial tube branching involved in lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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