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Proteintech
NRCAM Polyclonal Antibody
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Product Details
21608-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NRCAM Fusion Protein Ag16237 (446-628 aa encoded by BC098401)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EPPRILTPA NTLYQVIANR PALLDCAFFG SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL EIKDATWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVV (446-628 aa encoded by B C098401)
Target Information
Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ankyrin-binding cell adhesion molecule NrCAM; hBravo; mBravo; MGC138845; MGC138846; neuron-glia-CAM-related cell adhesion molecule; Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nr-CAM; rBravo
Gene Aliases: Bravo; C030017F07Rik; C130076O07Rik; KIAA0343; mKIAA0343; NRCAM
UniProt ID: (Human) Q92823, (Mouse) Q810U4
Entrez Gene ID: (Human) 4897, (Mouse) 319504, (Rat) 497815
angiogenesis
neuron migration
axonogenesis
axonal fasciculation
synapse assembly
central nervous system development
protein localization
single organismal cell-cell adhesion
neuronal action potential propagation
regulation of axon extension
retinal ganglion cell axon guidance
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
positive regulation of neuron differentiation
cell adhesion
axon guidance
regulation of neuron projection development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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