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Invitrogen
NRCAM Polyclonal Antibody
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FIGURE: 1 / 2
NRCAM Antibody (PA5-117357) in WB
Western blot analysis of NRCAM in Non-transfected (–) and transfected (+) 293T whole cell extracts (30 µg). Samples were separated with 5% SDS-PAGE and incubated in NRCAM polyclonal antibody (Product # PA5-117357) using a dilution of 1:1,000, followed by HRP-conjugated anti-rabbit IgG.
Product Details
PA5-117357
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human NRCAM. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.81 mg/mL
Amount
81 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
Neuron-glia-related cell adhesion molecule (NRCAM) is a gene located on chromosome 7q31.1, encoding a protein that belongs to the immunoglobulin superfamily of cell adhesion molecules. NRCAM is expressed in the nervous system and plays a vital role in the development and maintenance of neural connections. This adhesion molecule facilitates neuron-neuron and neuron-glia interactions, impacting processes such as axon guidance, synapse formation, and cell signaling, which are crucial for neural development and plasticity. NRCAM is involved in the modulation of signal transduction pathways that influence neuronal growth and repair, contributing to the stabilization of synaptic structures. Alterations in NRCAM expression or function have been linked to neurodevelopmental disorders, including autism spectrum disorders, and certain psychiatric conditions, reflecting its importance in maintaining neural circuit integrity. Research into NRCAM continues to explore its therapeutic potential in neurobiology and its implications in neurological and psychiatric disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ankyrin-binding cell adhesion molecule NrCAM; hBravo; KIAA0343; mBravo; MGC138845; MGC138846; neuron-glia-CAM-related cell adhesion molecule; Neuronal cell adhesion molecule; Neuronal surface protein Bravo; Ng-CAM-related; NgCAM-related cell adhesion molecule; Nr CAM; Nr-CAM; NrCAM; rBravo; unnamed protein product
Gene Aliases: Bravo; C030017F07Rik; C130076O07Rik; KIAA0343; mKIAA0343; NEDNMS; NRCAM
UniProt ID: (Human) Q92823, (Mouse) Q810U4
Entrez Gene ID: (Human) 4897, (Mouse) 319504, (Rat) 497815
angiogenesis
neuron migration
cell adhesion
axonogenesis
axon guidance
axonal fasciculation
synapse assembly
central nervous system development
brain development
protein localization
regulation of neuron projection development
neuronal action potential propagation
regulation of axon extension
retinal ganglion cell axon guidance
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
positive regulation of neuron differentiation
synapse organization
cell-cell adhesion
regulation of postsynapse organization
single organismal cell-cell adhesion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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