Product References
Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease.
PPAR research
Wang Y,Zhao W,Li G,Chen J,Guan X,Chen X,Guan Z
Thu Oct 01 00:00:00 EDT 2020
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
Frontiers in pharmacology
Zhang L,Chen Z,Gong W,Zou Y,Xu F,Chen L,Huang H
Thu Oct 01 00:00:00 EDT 2020
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1.
Frontiers in pharmacology
Zhang L,Chen Z,Gong W,Zou Y,Xu F,Chen L,Huang H
Thu Oct 01 00:00:00 EDT 2020
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Frontiers in cellular neuroscience
Hu Q,Li T,Wang L,Xie Y,Liu S,Bai X,Zhang T,Bo S,Xin D,Xue H,Li G,Wang Z
Thu Oct 01 00:00:00 EDT 2020
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Evidence-based complementary and alternative medicine : eCAM
Lin EY,Chagnaadorj A,Huang SJ,Wang CC,Chiang YH,Cheng CW
Wed Sep 30 00:00:00 EDT 2020
Hepatoprotective Activity of the Ethanolic Extract of Polygonum multiflorum Thunb. against Oxidative Stress-Induced Liver Injury.
Evidence-based complementary and alternative medicine : eCAM
Lin EY,Chagnaadorj A,Huang SJ,Wang CC,Chiang YH,Cheng CW
Wed Sep 30 00:00:00 EDT 2020
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis.
Frontiers in immunology
Ren Z,Li H,Zhang M,Zhao Y,Fang X,Li X,Chen W,Zhang H,Wang Y,Pan LL,Sun J
Thu Oct 03 00:00:00 EDT 2019
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Journal of cellular physiology
Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H
Mon Jul 01 00:00:00 EDT 2019
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Journal of cellular physiology
Liu H,Dong Y,Gao Y,Zhao L,Cai C,Qi D,Zhu M,Zhao L,Liu C,Guo F,Xiao J,Huang H
Mon Jul 01 00:00:00 EDT 2019
Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.
PloS one
Belcher JD,Gomperts E,Nguyen J,Chen C,Abdulla F,Kiser ZM,Gallo D,Levy H,Otterbein LE,Vercellotti GM
Wed Mar 20 00:00:00 EDT 2019
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Journal of cellular physiology
Zhong L,Hao H,Chen D,Hou Q,Zhu Z,He W,Sun S,Sun M,Li M,Fu X
Fri Mar 01 00:00:00 EST 2019
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
International immunopharmacology
He Y,Xia Z,Yu D,Wang J,Jin L,Huang D,Ye X,Li X,Zhang B
Fri Mar 01 00:00:00 EST 2019
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation.
Reproductive toxicology (Elmsford, N.Y.)
Hu Y,Wang Y,Yan T,Feng D,Ba Y,Zhang H,Zhu J,Cheng X,Cui L,Huang H
Fri Mar 01 00:00:00 EST 2019
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
The Journal of reproduction and development
Ullah O,Li Z,Ali I,Xu L,Liu H,Shah SZA,Fang N
Fri Feb 08 00:00:00 EST 2019
Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.
Molecular nutrition & food research
Lei P,Tian S,Teng C,Huang L,Liu X,Wang J,Zhang Y,Li B,Shan Y
Fri Feb 01 00:00:00 EST 2019
Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1β and promoting Nrf2/HO-1.
Molecular immunology
Song S,An J,Li Y,Liu S
Fri Feb 01 00:00:00 EST 2019
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Toxicology and applied pharmacology
Sha J,Zhang H,Zhao Y,Feng X,Hu X,Wang C,Song M,Fan H
Fri Feb 01 00:00:00 EST 2019
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Toxicology and applied pharmacology
Sha J,Zhang H,Zhao Y,Feng X,Hu X,Wang C,Song M,Fan H
Fri Feb 01 00:00:00 EST 2019
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Metabolic brain disease
Gao W,Wang W,Liu G,Zhang J,Yang J,Deng Z
Fri Feb 01 00:00:00 EST 2019
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Toxicology
Huang J,Lu Y,Zhang B,Yang S,Zhang Q,Cui H,Lu X,Zhao Y,Yang X,Li R
Tue Jan 15 00:00:00 EST 2019
Differential response to lead toxicity in rat primary microglia and astrocytes.
Toxicology and applied pharmacology
Peng J,Zhou F,Wang Y,Xu Y,Zhang H,Zou F,Meng X
Tue Jan 15 00:00:00 EST 2019
Differential response to lead toxicity in rat primary microglia and astrocytes.
Toxicology and applied pharmacology
Peng J,Zhou F,Wang Y,Xu Y,Zhang H,Zou F,Meng X
Tue Jan 15 00:00:00 EST 2019
Nrf2 protects stellate cells from Smad-dependent cell activation.
PloS one
Prestigiacomo V,Suter-Dick L
Mon Jan 14 00:00:00 EST 2019
Nrf2 protects stellate cells from Smad-dependent cell activation.
PloS one
Prestigiacomo V,Suter-Dick L
Mon Jan 14 00:00:00 EST 2019
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Song Q,Zhang Y,Han X,Zhang Y,Zhang X,Gao Y,Zhang J,Chu L,Zhao S
Tue Jan 01 00:00:00 EST 2019
Naringenin targets on astroglial Nrf2 to support dopaminergic neurons.
Pharmacological research
Wang GQ,Zhang B,He XM,Li DD,Shi JS,Zhang F
Tue Jan 01 00:00:00 EST 2019
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Journal of molecular neuroscience : MN
Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X
Tue Jan 01 00:00:00 EST 2019
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Journal of molecular neuroscience : MN
Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X
Tue Jan 01 00:00:00 EST 2019
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Journal of ethnopharmacology
Yang WJ,Li YR,Gao H,Wu XY,Wang XL,Wang XN,Xiang L,Ren DM,Lou HX,Shen T
Wed Dec 05 00:00:00 EST 2018
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice.
Journal of ethnopharmacology
Yang WJ,Li YR,Gao H,Wu XY,Wang XL,Wang XN,Xiang L,Ren DM,Lou HX,Shen T
Wed Dec 05 00:00:00 EST 2018
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Phytotherapy research : PTR
Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P
Sat Dec 01 00:00:00 EST 2018
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Ecotoxicology and environmental safety
Duan J,Kang J,Qin W,Deng T,Liu H,Li B,Yu W,Gong S,Yang X,Chen M
Thu Nov 15 00:00:00 EST 2018
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Biochemical and biophysical research communications
Zhang LM,Zhang J,Zhang Y,Wang L,Fei C,Yi ZW,Dong L
Fri Nov 02 00:00:00 EDT 2018
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
International immunopharmacology
Rong Y,Cao B,Liu B,Li W,Chen Y,Chen H,Liu Y,Liu T
Thu Nov 01 00:00:00 EDT 2018
A novel Gallic acid derivative attenuates BLM-induced pulmonary fibrosis in mice.
International immunopharmacology
Rong Y,Cao B,Liu B,Li W,Chen Y,Chen H,Liu Y,Liu T
Thu Nov 01 00:00:00 EDT 2018
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Journal of cellular biochemistry
Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S
Thu Nov 01 00:00:00 EDT 2018
Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
Biological trace element research
Khaliq H,Jing W,Ke X,Ke-Li Y,Peng-Peng S,Cui L,Wei-Wei Q,Zhixin L,Hua-Zhen L,Hui S,Ju-Ming Z,Ke-Mei P
Thu Nov 01 00:00:00 EDT 2018
Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.
Molecular and cellular biochemistry
Chen S,Zhou Y,Zhou L,Guan Y,Zhang Y,Han X
Thu Nov 01 00:00:00 EDT 2018
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
Journal of cellular biochemistry
Li Y,Chen Y,Qiu C,Ma X,Lei K,Cai G,Liang X,Liu J
Tue Oct 30 00:00:00 EDT 2018
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Oxidative medicine and cellular longevity
Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T
Mon Oct 22 00:00:00 EDT 2018
Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice.
Food & function
Zhai X,Lin D,Zhao Y,Li W,Yang X
Wed Oct 17 00:00:00 EDT 2018
Renoprotective Effects of Antroquinonol in Rats with Nω-Nitro-l-Arginine Methyl Ester-Induced Hypertension.
Nutrients
Chen JR,Ko J,Yeh WJ,Huang WC,Yang HY
Wed Oct 17 00:00:00 EDT 2018
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP
Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K
Mon Oct 01 00:00:00 EDT 2018
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Zhao F,Lei F,Yan X,Zhang S,Wang W,Zheng Y
Mon Sep 10 00:00:00 EDT 2018
Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Zhao F,Lei F,Yan X,Zhang S,Wang W,Zheng Y
Mon Sep 10 00:00:00 EDT 2018
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Journal of applied toxicology : JAT
Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S
Sat Sep 01 00:00:00 EDT 2018
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
International journal of oncology
Zhang TT,Qu N,Sun GH,Zhang L,Wang YJ,Mu XM,Wei WJ,Wang YL,Wang Y,Ji QH,Zhu YX,Shi RL
Wed Aug 01 00:00:00 EDT 2018
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Molecular and cellular endocrinology
Akino N,Wada-Hiraike O,Terao H,Honjoh H,Isono W,Fu H,Hirano M,Miyamoto Y,Tanikawa M,Harada M,Hirata T,Hirota Y,Koga K,Oda K,Kawana K,Fujii T,Osuga Y
Sun Jul 15 00:00:00 EDT 2018
Activation of Nrf2 might reduce oxidative stress in human granulosa cells.
Molecular and cellular endocrinology
Akino N,Wada-Hiraike O,Terao H,Honjoh H,Isono W,Fu H,Hirano M,Miyamoto Y,Tanikawa M,Harada M,Hirata T,Hirota Y,Koga K,Oda K,Kawana K,Fujii T,Osuga Y
Sun Jul 15 00:00:00 EDT 2018
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
Oxidative medicine and cellular longevity
Liao HH,Zhu JX,Feng H,Ni J,Zhang N,Chen S,Liu HJ,Yang Z,Deng W,Tang QZ
Mon Jul 09 00:00:00 EDT 2018
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1.
Oxidative medicine and cellular longevity
Liao HH,Zhu JX,Feng H,Ni J,Zhang N,Chen S,Liu HJ,Yang Z,Deng W,Tang QZ
Mon Jul 09 00:00:00 EDT 2018
β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice.
Nutrients
Xu X,Ding Y,Yang Y,Gao Y,Sun Q,Liu J,Yang X,Wang J,Zhang J
Tue Jul 03 00:00:00 EDT 2018
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Molecular medicine reports
Xue S,He W,Zeng X,Tang Z,Feng S,Zhong Z,Xiong Y,Wang Y,Ye Q
Sun Jul 01 00:00:00 EDT 2018
LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Gao M,Li C,Xu M,Liu Y,Cong M,Liu S
Sun Jul 01 00:00:00 EDT 2018
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gao W,Xiao C,Hu J,Chen B,Wang C,Cui B,Deng P,Yang J,Deng Z
Sun Jul 01 00:00:00 EDT 2018
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Oncotarget
Evans JP,Winiarski BK,Sutton PA,Jones RP,Ressel L,Duckworth CA,Pritchard DM,Lin ZX,Fretwell VL,Tweedle EM,Costello E,Goldring CE,Copple IM,Park BK,Palmer DH,Kitteringham NR
Tue Jun 05 00:00:00 EDT 2018
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Neurochemistry international
Zhang J,Tucker LD,Lu Y,Yang L,Wu C,Li Y,Zhang Q
Fri Jun 01 00:00:00 EDT 2018
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Neurochemistry international
Zhang J,Tucker LD,Lu Y,Yang L,Wu C,Li Y,Zhang Q
Fri Jun 01 00:00:00 EDT 2018
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Free radical biology & medicine
Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z
Sun May 20 00:00:00 EDT 2018
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Free radical biology & medicine
Li H,Tang Z,Chu P,Song Y,Yang Y,Sun B,Niu M,Qaed E,Shopit A,Han G,Ma X,Peng J,Hu M,Tang Z
Sun May 20 00:00:00 EDT 2018
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis.
Experimental animals
Akiyama K,Warabi E,Okada K,Yanagawa T,Ishii T,Kose K,Tokushige K,Ishige K,Mizokami Y,Yamagata K,Onizawa K,Ariizumi SI,Yamamoto M,Shoda J
Thu May 10 00:00:00 EDT 2018
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L
Tue May 01 00:00:00 EDT 2018
Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Redox biology
Li D,Wang X,Huang Q,Li S,Zhou Y,Li Z
Tue May 01 00:00:00 EDT 2018
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
ACS chemical neuroscience
Dai C,Ciccotosto GD,Cappai R,Wang Y,Tang S,Hoyer D,Schneider EK,Velkov T,Xiao X
Wed Apr 18 00:00:00 EDT 2018
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications.
Biochemical pharmacology
Wang Z,Yuan S,Li Y,Zhang Z,Xiao W,Tang D,Ye K,Liu Z,Wang C,Zheng Y,Nie H,Chen H
Sun Apr 01 00:00:00 EDT 2018
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Zhang X,Wang Y,Velkov T,Tang S,Dai C
Sun Apr 01 00:00:00 EDT 2018
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Zhang X,Wang Y,Velkov T,Tang S,Dai C
Sun Apr 01 00:00:00 EDT 2018
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Journal of neuroinflammation
Paraiso HC,Kuo PC,Curfman ET,Moon HJ,Sweazey RD,Yen JH,Chang FL,Yu IC
Thu Mar 29 00:00:00 EDT 2018
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
International journal of molecular sciences
Tang X,Liu B,Wang X,Yu Q,Fang R
Wed Mar 14 00:00:00 EDT 2018
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Theranostics
Feng L,Li J,Yang L,Zhu L,Huang X,Zhang S,Luo L,Jiang Z,Jiang T,Xu W,Wang X,Jin H
Tue Mar 06 00:00:00 EST 2018
Tamoxifen activates Nrf2-dependent SQSTM1 transcription to promote endometrial hyperplasia.
Theranostics
Feng L,Li J,Yang L,Zhu L,Huang X,Zhang S,Luo L,Jiang Z,Jiang T,Xu W,Wang X,Jin H
Tue Mar 06 00:00:00 EST 2018
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Toxicology letters
Qiao Y,Xu L,Tao X,Yin L,Qi Y,Xu Y,Han X,Tang Z,Ma X,Liu K,Peng J
Thu Mar 01 00:00:00 EST 2018
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Free radical biology & medicine
Meng N,Tang H,Zhang H,Jiang C,Su L,Min X,Zhang W,Zhang H,Miao Z,Zhang W,Zhuang C
Thu Mar 01 00:00:00 EST 2018
Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis.
Free radical biology & medicine
Meng N,Tang H,Zhang H,Jiang C,Su L,Min X,Zhang W,Zhang H,Miao Z,Zhang W,Zhuang C
Thu Mar 01 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus.
eLife
Wible RS,Ramanathan C,Sutter CH,Olesen KM,Kensler TW,Liu AC,Sutter TR
Mon Feb 26 00:00:00 EST 2018
Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.
Respiratory research
Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J
Mon Feb 12 00:00:00 EST 2018
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zheng L,Yin L,Xu L,Qi Y,Li H,Xu Y,Han X,Liu K,Peng J
Mon Jan 01 00:00:00 EST 2018
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Molecular neurobiology
Dai C,Ciccotosto GD,Cappai R,Tang S,Li D,Xie S,Xiao X,Velkov T
Mon Jan 01 00:00:00 EST 2018
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury.
International immunopharmacology
Shi A,Shi H,Wang Y,Liu X,Cheng Y,Li H,Zhao H,Wang S,Dong L
Mon Jan 01 00:00:00 EST 2018
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Environmental toxicology
Lin EY,Bayarsengee U,Wang CC,Chiang YH,Cheng CW
Mon Jan 01 00:00:00 EST 2018
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Environmental toxicology
Lin EY,Bayarsengee U,Wang CC,Chiang YH,Cheng CW
Mon Jan 01 00:00:00 EST 2018
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Biochemical and biophysical research communications
Liu M,Xu H,Zhang L,Zhang C,Yang L,Ma E,Liu L,Li Y
Mon Jan 01 00:00:00 EST 2018
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
World journal of gastroenterology
Sang L,Wang XM,Xu DY,Sang LX,Han Y,Jiang LY
Thu Dec 21 00:00:00 EST 2017
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Du L,Lei Y,Chen J,Song H,Wu X
Mon Dec 18 00:00:00 EST 2017
Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway.
Experimental gerontology
Zhang J,Tong W,Sun H,Jiang M,Shen Y,Liu Y,Gu H,Guo J,Fang J,Jin L
Fri Dec 15 00:00:00 EST 2017
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Cancer cell
Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y
Mon Nov 13 00:00:00 EST 2017
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Cancer cell
Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y
Mon Nov 13 00:00:00 EST 2017
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
Oncotarget
Huang R,Li X,Yu Y,Ma L,Liu S,Zong X,Zheng Q
Tue Nov 07 00:00:00 EST 2017
An inducible form of Nrf2 confers enhanced protection against acute oxidative stresses in RPE cells.
Experimental eye research
Vu KT,Hulleman JD
Wed Nov 01 00:00:00 EDT 2017
Carbon monoxide released from its pharmacological donor, tricarbonyldichlororuthenium (II) dimer, accelerates the healing of pre-existing gastric ulcers.
British journal of pharmacology
Magierowski M,Magierowska K,Hubalewska-Mazgaj M,Sliwowski Z,Ginter G,Pajdo R,Chmura A,Kwiecien S,Brzozowski T
Sun Oct 01 00:00:00 EDT 2017
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress.
Redox biology
Liu S,Xin D,Wang L,Zhang T,Bai X,Li T,Xie Y,Xue H,Bo S,Liu D,Wang Z
Sun Oct 01 00:00:00 EDT 2017
The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Magierowski M,Magierowska K,Surmiak M,Hubalewska-Mazgaj M,Kwiecien S,Wallace JL,Brzozowski T
Sun Oct 01 00:00:00 EDT 2017
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu J,Wang L,Du Y,Liu S
Sun Oct 01 00:00:00 EDT 2017
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Li D,Dai C,Yang X,Wang F,Yu X,Xiao X,Tang S
Sun Oct 01 00:00:00 EDT 2017
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Duan L,Li J,Ma P,Yang X,Xu S
Fri Sep 01 00:00:00 EDT 2017
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Experimental and therapeutic medicine
Li L,Kong L,Song H
Fri Sep 01 00:00:00 EDT 2017
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo.
Scientific reports
Zhao X,Dong W,Gao Y,Shin DS,Ye Q,Su L,Jiang F,Zhao B,Miao J
Tue Jun 20 00:00:00 EDT 2017
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Biomaterials
Gao M,Zhao B,Chen M,Liu Y,Xu M,Wang Z,Liu S,Zhang C
Thu Jun 01 00:00:00 EDT 2017
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Brain, behavior, and immunity
Kuo PC,Yu IC,Scofield BA,Brown DA,Curfman ET,Paraiso HC,Chang FL,Yen JH
Mon May 01 00:00:00 EDT 2017
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
International journal of molecular medicine
Wang H,Xu YS,Wang ML,Cheng C,Bian R,Yuan H,Wang Y,Guo T,Zhu LL,Zhou H
Sat Apr 01 00:00:00 EDT 2017
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Redox biology
Zhang C,Li C,Chen S,Li Z,Jia X,Wang K,Bao J,Liang Y,Wang X,Chen M,Li P,Su H,Wan JB,Lee SMY,Liu K,He C
Sat Apr 01 00:00:00 EDT 2017
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Oxidative medicine and cellular longevity
Wang Y,Gu YH,Liu M,Bai Y,Liang LY,Wang HL
Mon Mar 27 00:00:00 EDT 2017
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Oxidative medicine and cellular longevity
Hou CL,Wang MJ,Sun C,Huang Y,Jin S,Mu XP,Chen Y,Zhu YC
Mon Mar 13 00:00:00 EDT 2017
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Toxicology mechanisms and methods
Dai C,Lei L,Li B,Lin Y,Xiao X,Tang S
Wed Mar 01 00:00:00 EST 2017
Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediated mitogen activated protein kinases pathway.
World journal of gastroenterology
Yang N,Shi JJ,Wu FP,Li M,Zhang X,Li YP,Zhai S,Jia XL,Dang SS
Tue Feb 21 00:00:00 EST 2017
Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).
Scientific reports
Kemter E,Fröhlich T,Arnold GJ,Wolf E,Wanke R
Tue Feb 21 00:00:00 EST 2017
NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway.
The Journal of biological chemistry
Bernard K,Logsdon NJ,Miguel V,Benavides GA,Zhang J,Carter AB,Darley-Usmar VM,Thannickal VJ
Fri Feb 17 00:00:00 EST 2017
Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats.
Molecular medicine reports
Wang Y,Gu YH,Liu M,Bai Y,Wang HL
Wed Feb 01 00:00:00 EST 2017
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
PLoS pathogens
Basu M,Courtney SC,Brinton MA
Wed Feb 01 00:00:00 EST 2017
Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells.
PLoS pathogens
Basu M,Courtney SC,Brinton MA
Wed Feb 01 00:00:00 EST 2017
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Shen S,Li J,You H,Wu Z,Wu Y,Zhao Y,Zhu Y,Guo Q,Li X,Li R,Ma P,Yang X,Chen M
Sun Jan 01 00:00:00 EST 2017
Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu YR,Ma H,Zou ZY,He K,Xiao YB,Wang Y,Feng M,Ye XL,Li XG
Sun Jan 01 00:00:00 EST 2017
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Clinical nutrition (Edinburgh, Scotland)
Shi H,Shi A,Dong L,Lu X,Wang Y,Zhao J,Dai F,Guo X
Thu Dec 01 00:00:00 EST 2016
Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.
Transplantation proceedings
Zhang P,Li Y,Du Y,Li G,Wang L,Zhou F
Thu Dec 01 00:00:00 EST 2016
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Free radical biology & medicine
Lu L,Dong J,Li D,Zhang J,Fan S
Sat Oct 01 00:00:00 EDT 2016
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Chemico-biological interactions
Han X,Li W,Huang D,Yang X
Sun Sep 25 00:00:00 EDT 2016
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Acta pharmacologica Sinica
Zhou ZY,Ren LW,Zhan P,Yang HY,Chai DD,Yu ZW
Mon Aug 01 00:00:00 EDT 2016
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Renal failure
Zhang W,Li Y,Ding H,Du Y,Wang L
Mon Aug 01 00:00:00 EDT 2016
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
PloS one
Gao Z,Han Y,Hu Y,Wu X,Wang Y,Zhang X,Fu J,Zou X,Zhang J,Chen X,Jose PA,Lu X,Zeng C
Mon Jul 25 00:00:00 EDT 2016
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Molecules (Basel, Switzerland)
Zhao L,Xu L,Tao X,Han X,Yin L,Qi Y,Peng J
Thu Jul 21 00:00:00 EDT 2016
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Nutrients
Tao X,Sun X,Xu L,Yin L,Han X,Qi Y,Xu Y,Zhao Y,Wang C,Peng J
Fri Jul 08 00:00:00 EDT 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 EDT 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 EDT 2016
Taurine protects against As2O3-induced autophagy in livers of rat offsprings through PPARγ pathway.
Scientific reports
Bai J,Yao X,Jiang L,Zhang Q,Guan H,Liu S,Wu W,Qiu T,Gao N,Yang L,Yang G,Sun X
Mon Jun 13 00:00:00 EDT 2016
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Cell & bioscience
Liu J,Wu J,Sun A,Sun Y,Yu X,Liu N,Dong S,Yang F,Zhang L,Zhong X,Xu C,Lu F,Zhang W
Wed May 25 00:00:00 EDT 2016
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Cell & bioscience
Liu J,Wu J,Sun A,Sun Y,Yu X,Liu N,Dong S,Yang F,Zhang L,Zhong X,Xu C,Lu F,Zhang W
Wed May 25 00:00:00 EDT 2016
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chen K,Li J,Li S,Feng J,Wu L,Liu T,Zhang R,Xu S,Cheng K,Zhou Y,Zhou S,Wang F,Dai W,Xia Y,Lu J,Zhou Y,Guo C
Sun May 01 00:00:00 EDT 2016
Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway.
Biochimie
Bai J,Yao X,Jiang L,Qiu T,Liu S,Qi B,Zheng Y,Kong Y,Yang G,Chen M,Liu X,Sun X
Fri Apr 01 00:00:00 EDT 2016
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Deng S,Tang S,Dai C,Zhou Y,Yang X,Li D,Xiao X
Mon Feb 01 00:00:00 EST 2016
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Journal of agricultural and food chemistry
Su C,Xia X,Shi Q,Song X,Fu J,Xiao C,Chen H,Lu B,Sun Z,Wu S,Yang S,Li X,Ye X,Song E,Song Y
Wed Jun 10 00:00:00 EDT 2015
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
International journal of clinical and experimental pathology
Zhao F,Li K,Zhao L,Liu J,Suo Q,Zhao J,Wang H,Zhao S
Tue May 26 00:00:00 EDT 2015
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
International journal of clinical and experimental pathology
Zhao F,Li K,Zhao L,Liu J,Suo Q,Zhao J,Wang H,Zhao S
Tue May 26 00:00:00 EDT 2015
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Chemical research in toxicology
Su C,Zhang P,Song X,Shi Q,Fu J,Xia X,Bai H,Hu L,Xu D,Song E,Song Y
Mon Apr 20 00:00:00 EDT 2015
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Chemical research in toxicology
Su C,Zhang P,Song X,Shi Q,Fu J,Xia X,Bai H,Hu L,Xu D,Song E,Song Y
Mon Apr 20 00:00:00 EDT 2015
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Chemical research in toxicology
Su C,Zhang P,Song X,Shi Q,Fu J,Xia X,Bai H,Hu L,Xu D,Song E,Song Y
Mon Apr 20 00:00:00 EDT 2015
Transcriptional upregulation centra of HO-1 by EGB via the MAPKs/Nrf2 pathway in mouse C2C12 myoblasts.
Toxicology in vitro : an international journal published in association with BIBRA
Wang J,Zhang L,Zhang Y,Luo M,Wu Q,Yu L,Chu H
Sun Mar 01 00:00:00 EST 2015
Potent effects of dioscin against obesity in mice.
Scientific reports
Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J
Thu Jan 22 00:00:00 EST 2015
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Food & function
Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J
Mon Dec 01 00:00:00 EST 2014
basic leucine zipper transcription factor
