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Proteintech

NRG1 Polyclonal Antibody

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View all (26) NRG1 antibodies

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NRG1 Polyclonal Antibody

Product Details

10527-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 6 publications 6 publications

Immunohistochemistry (IHC)

-
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NRG1 Fusion Protein Ag0803 (1-225 aa encoded by BC007675)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Amount

66 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEIYSPDMS EVAAERSSSP STQLSADPSL DGLPAAEDMP EPQTEDGRTP GLVGLAVPCC ACLEAERLRG CLNSEKICIV PILACLVSLC LCIAGLKWVF VDKIFEYDSP THLDPGGLGQ DPIISLDATA ASALWVSSEA YTSPVSRAQS ESEVQVTVQG DKAVVSFEPS AAPTPKNRIF AFSFLPSTAP SFPSPTRNPE VRTPKSATQP QTTETNLQTA PKLSTS (1-225 aa encoded by B C007675)

Target Information

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; NRG-1; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1; unnamed protein product

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Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) Q02297, (Mouse) Q6DR98

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Entrez Gene ID: (Human) 3084, (Mouse) 211323

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Function(s)
transcription cofactor activity receptor binding cytokine activity integrin binding protein binding growth factor activity zinc ion binding nickel cation binding protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity receptor agonist activity ErbB-2 class receptor binding growth factor
Process(es)
ventricular trabecula myocardium morphogenesis cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development brain development peripheral nervous system development cell proliferation positive regulation of cell proliferation regulation of cell communication negative regulation of cardiac muscle cell apoptotic process neural crest cell development regulation of signaling cell differentiation positive regulation of cell growth mammary gland development positive regulation of protein complex assembly activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB3 signaling pathway ERBB4 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway wound healing positive regulation of cell adhesion negative regulation of transcription, DNA-templated negative chemotaxis negative regulation of secretion positive regulation of developmental process positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation regulation of biological quality positive regulation of ERK1 and ERK2 cascade regulation of postsynaptic neurotransmitter receptor internalization positive regulation of peptidyl-tyrosine autophosphorylation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand MAPK cascade cell morphogenesis cardiac conduction system development activation of transmembrane receptor protein tyrosine kinase activity synapse assembly heart development muscle organ development locomotory behavior axon ensheathment glial cell differentiation cell migration glial cell fate commitment positive regulation of myelination negative regulation of protein catabolic process cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of protein kinase activity positive regulation of Ras protein signal transduction neuron fate commitment oligodendrocyte differentiation positive regulation of protein kinase B signaling positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation
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