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NRG3 Polyclonal Antibody
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Product Details
BS-6235R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NRG3, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3. NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EGF-like domain protein family member; HGNC:7999; neuregulin 3; neuregulin-3-like polypeptide; NRG-3-LP; growth factor activity in neurons; Pro-neuregulin-3, membrane-bound isoform; Pro-NRG3; scaramanga; unnamed protein product
Gene Aliases: HRG3; NRG3; pro-NRG3; RGD1559678; ska
UniProt ID: (Human) A4D7U1, (Mouse) O35181
Entrez Gene ID: (Human) 10718, (Rat) 498596, (Mouse) 18183
regulation of cell growth
pattern specification process
nervous system development
synapse assembly
chemorepulsion involved in interneuron migration from the subpallium to the cortex
mammary gland development
intracellular signal transduction
ERBB4 signaling pathway
ERBB4-ERBB4 signaling pathway
animal organ development
modulation of synaptic transmission
mammary placode formation
negative regulation of neuron migration
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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