This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
This target displays homology in the following species: Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Neurogranin is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
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Protein Aliases: B-50 immunoreactive C-kinase substrate; BICKS; calmodulin-binding protein; hng; NEUG(55-78); Neurogranin; neurogranin (protein kinase C substrate, RC3); neurogranin-like; NG; NRGN; p17; postsynaptic spine 1; protein kinase C substrate; Protein kinase C substrate 7.5 kDa protein; protein kinase C substrate, RC3; RC3
Gene Aliases: 0710001B06Rik; AI838505; BOS_24593; hng; NG; NG/RC3; NRGN; Pss1; R75334; RC3