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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 1 and 44 of Human NSD2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28409 targets NSD2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28409 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 44 of Human NSD2.
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL5 promoter REII region-binding protein; MMSET; multiple myeloma SET domain containing protein type III; NSD2; nuclear receptor binding SET domain protein 2; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; REIIBP; trithorax/ash1-related protein 5; TRX5; WHS
KIAA1090; MMSET; NSD2; REIIBP; TRX5; WHS; WHSC1