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Invitrogen
NSE2 Polyclonal Antibody
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Product Details
PA5-64243
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NSMCE2. Recombinant protein control fragment (Product #RP-104203).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QNNEKFVQFK QQLKELKKQC GLQADREADG TEGVDEDIIV TQS
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 77%.
Target Information
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; FLJ32440; hMMS21; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; Non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase; NSMCE2/PVT1 fusion; PVT1/NSMCE2 fusion; unnamed protein product; zinc finger, MIZ-type containing 7
Gene Aliases: C8orf36; MMS21; NSE2; NSMCE2; ZMIZ7
UniProt ID: (Human) Q96MF7
Entrez Gene ID: (Human) 286053
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
protein sumoylation
regulation of telomere maintenance
positive regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of mitotic metaphase/anaphase transition
cell division
cellular senescence
chromatin looping
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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