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Invitrogen
NSG1 Polyclonal Antibody
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Product Details
PA5-36497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 130-180 of human NEEP21
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 21 kDa.
Purity is >95% by SDS-PAGE.
Target Information
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain neuron cytoplasmic protein 1; Brain neuron cytoplasmic protein 1/2; brain specific mRNA b; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; M234; neuron specific gene family member 1; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; Neuronal vesicle trafficking-associated protein 1; p21; unnamed protein product
Gene Aliases: Bsmrb; D4S234; D4S234E; m234; NEEP21; NSG1; P21; PEP1
UniProt ID: (Human) P42857, (Mouse) Q62092, (Rat) P02683
Entrez Gene ID: (Human) 27065, (Mouse) 18196, (Rat) 25247
receptor recycling
positive regulation of receptor recycling
apoptotic process
endosomal transport
amyloid precursor protein metabolic process
clathrin coat assembly
spontaneous synaptic transmission
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
neurotransmitter receptor cycle
postsynaptic neurotransmitter receptor cycle
regulation of long-term synaptic potentiation
dopamine receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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