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Invitrogen
NSG1 Polyclonal Antibody
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FIGURE: 1 / 3
NSG1 Antibody (PA5-37939) in ICC/IF
Immunocytochemistry analysis of NSG1 using NSG1 Polyclonal Antibody (Product # PA5-37939) (3 µg/mL) in DIV9 cells from Hippocampus E18 Rat embryos showed exclusive localization (red, Alexa 568) within the neurons (MAP2 staining in blue, Alexa 647) and not in the glia (GFAP staining in green, Alexa 488).Right panel shows the same cells in phase contrast. Data obtained from Dr C.C. Yap, University of Virginia Medical School, USA.
Product Details
PA5-37939
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence EKGTKQPLLEDGFD-C, from the N-terminus of Nsg1 (aa 10-23).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with human and cow based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain neuron cytoplasmic protein 1; Brain neuron cytoplasmic protein 1/2; brain specific mRNA b; M234; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; Neuronal vesicle trafficking-associated protein 1; p21
Gene Aliases: Bsmrb; m234; NEEP21; Nsg1; p21; PEP1
UniProt ID: (Mouse) Q62092, (Rat) P02683
Entrez Gene ID: (Mouse) 18196, (Rat) 25247
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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