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Proteintech
NSMCE2 Polyclonal Antibody
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Product Details
13627-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NSMCE2 Fusion Protein Ag4545 (1-247 aa encoded by BC032797)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPGRSSSNS GSTGFISFSG VESALSSLKN FQACINSGMD TASSVALDLV ESQTEVSSEY SMDKAMVEFA TLDRQLNHYV KAVQSTINHV KEERPEKIPD LKLLVEKKFL ALQSKNSDAD FQNNEKFVQF KQQLKELKKQ CGLQADREAD GTEGVDEDII VTQSQTNFTC PITKEEMKKP VKNKVCGHTY EEDAIVRMIE SRQKRKKKAY CPQIGCSHTD IRKSDLIQDE ALRRAIENHN KKRHRHSE (1-247 aa encoded by BC032797)
Target Information
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; FLJ32440; hMMS21; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; Non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase; NSMCE2/PVT1 fusion; PVT1/NSMCE2 fusion; unnamed protein product; zinc finger, MIZ-type containing 7
Gene Aliases: 1110014D18Rik; AI661537; C8orf36; MMS21; NSE2; NSMCE2; RGD1305156; ZMIZ7
UniProt ID: (Human) Q96MF7, (Mouse) Q91VT1, (Rat) Q4V8A0
Entrez Gene ID: (Human) 286053, (Mouse) 68501, (Rat) 299957
protein binding
zinc ion binding
transferase activity
SUMO transferase activity
metal ion binding
SUMO ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
protein sumoylation
regulation of telomere maintenance
positive regulation of maintenance of mitotic sister chromatid cohesion
positive regulation of mitotic metaphase/anaphase transition
cell division
cellular senescence
chromatin looping
cell cycle
mitotic nuclear division
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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