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Proteintech
NSUN2 Polyclonal Antibody
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Product Details
20854-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NSUN2 Fusion Protein Ag14791 (415-767 aa encoded by BC001041)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: HHQNTGGFF VAVLVKKSSM PWNKRQPKLQ GKSAETREST QLSPADLTEG KPTDPSKLES PSFTGTGDTE IAHATEDLEN NGSKKDGVCG PPPSKKMKLF GFKEDPFVFI PEDDPLFPPI EKFYALDPSF PRMNLLTRTT EGKKRQLYMV SKELRNVLLN NSEKMKVINT GIKVWCRNNS GEEFDCAFRL AQEGIYTLYP FINSRIITVS MEDVKILLTQ ENPFFRKLSS ETYSQAKDLA KGSIVLKYEP DSANPDALQC PIVLCGWRGK ASIRTFVPKN ERLHYLRMMG LEVLGEKKKE GVILTNESAA STGQPDNDVT EGQRAGEPNS PDAEEANSPD VTAGCDPAGV HPPR (415-767 aa encoded by B C001041)
Target Information
NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-methycytoisine methyltransferase; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; Myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; RNA cytosine C(5)-methyltransferase NSUN2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog; unnamed protein product
Gene Aliases: MISU; MRT5; NSUN2; SAKI; TRM4
UniProt ID: (Human) Q08J23
Entrez Gene ID: (Human) 54888
RNA methylation
in utero embryonic development
mRNA processing
tRNA modification
spermatogenesis
spermatid development
tRNA processing
regulation of mRNA export from nucleus
cell differentiation
tRNA methylation
methylation
meiotic cell cycle checkpoint
tRNA stabilization
hair follicle maturation
cell division
regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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