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Proteintech
NSUN2 Polyclonal Antibody, CoraLite® Plus 488
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FIGURE: 1 / 1
NSUN2 Antibody (CL488-20854) in Flow
1x10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human NSUN2 (CL488-20854) (red), or 0.4 µg CoraLite® Plus 488-conjugated Rabbit IgG control Rabbit PolyAb (CL488-30000) (blue). Cells were fixed and permeabilized with True-Nuclear Transcription Factor Buffer Set.
Product Details
CL488-20854
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NSUN2 fusion protein Ag14791
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HHQNTGGFFV AVLVKKSSMP WNKRQPKLQG KSAETRESTQ LSPADLTEGK PTDPSKLESP SFTGTGDTEI AHATEDLENN GSKKDGVCGP PPSKKMKLFG FKEDPFVFIP EDDPLFPPIE KFYALDPSFP RMNLLTRTTE GKKRQLYMVS KELRNVLLNN SEKMKVINTG IKVWCRNNSG EEFDCAFRLA QEGIYTLYPF INSRIITVSM EDVKILLTQE NPFFRKLSSE TYSQAKDLAK GSIVLKYEPD SANPDALQCP IVLCGWRGKA SIRTFVPKNE RLHYLRMMGL EVLGEKKKEG VILTNESAAS TGQPDNDVTE GQRAGEPNSP DAEEANSPDV TAGCDPAGVH PPR
Target Information
NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu(CAA). Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu(CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Mutations of NSUN2 result in autosomal recessive 5 mental retardation (MRT5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-methycytoisine methyltransferase; hTrm4; Misu; mRNA cytosine C(5)-methyltransferase; Myc-induced SUN domain-containing protein; Myc-induced SUN-domain-containing protein; NOL1/NOP2/Sun domain family member 2; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family member 2; RNA cytosine C(5)-methyltransferase NSUN2; Substrate of AIM1/Aurora kinase B; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2; tRNA cytosine C(5)-methyltransferase; tRNA methyltransferase 4 homolog; unnamed protein product
Gene Aliases: MISU; MRT5; NSUN2; SAKI; TRM4
UniProt ID: (Human) Q08J23
Entrez Gene ID: (Human) 54888
RNA methylation
in utero embryonic development
mRNA processing
tRNA modification
spermatogenesis
spermatid development
tRNA processing
regulation of mRNA export from nucleus
cell differentiation
tRNA methylation
methylation
meiotic cell cycle checkpoint
tRNA stabilization
hair follicle maturation
cell division
regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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