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Proteintech

NSUN5 Polyclonal Antibody

11 References
View all (7) NSUN5 antibodies

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Product Details

15449-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 6 publications 6 publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 3 publications 3 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NSUN5 Fusion Protein Ag7711 (117-466 aa encoded by BC008084)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Amount

31.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RNEDLLEVG SRPGPASQLP RFVRVNTLKT CSDDVVDYFK RQGFSYQGRA SSLDDLRALK GKHFLLDPLM PELLVFPAQT DLHEHPLYRA GHLILQDRAS CLPAMLLDPP PGSHVIDACA APGNKTSHLA ALLKNQGKIF AFDLDAKRLA SMATLLARAG VSCCELAEED FLAVSPSDPR YHEVHYILLD PSCSGSGMPS RQLEEPGAGT PSPVRLHALA GFQQRALCHA LTFPSLQRLV YSTCSLCQEE NEDVVRDALQ QNPGAFRLAP ALPAWPHRGL STFPGAEHCL RASPETTLSS GFFVAVIERV EVPSSASQAK ASAPERTPSP APKRKKRQQR AAAGACTPPC T (117-466 aa encoded by BC008084)

Target Information

NSUN5 is a member of the evolutionarily conserved NOL1/NOP2/Sun domain family. The encoded protein may function as a DNA methyltransferase in the nucleus. The gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 28S rRNA (cytosine-C(5))-methyltransferase; FLJ10267; MGC986; NOL1-related protein; NOL1/NOP2/Sun domain family member 5; NOL1/NOP2/Sun domain family, member 5; NOL1R; NOP2/Sun domain family, member 5; NOP2/Sun domain family, member 5A; NOP2/Sun RNA methyltransferase family member 5; probable 28S rRNA (cytosine-C(5))-methyltransferase; putative methyltransferase NSUN5; unnamed protein product; Williams Beuren syndrome chromosome region 20A; Williams Beuren syndrome chromosome region 20A homolog; Williams-Beuren syndrome chromosomal region 20A protein; Williams-Beuren syndrome chromosomal region 20A protein homolog; Williams-Beuren syndrome critical region protein 20; Williams-Beuren syndrome critical region protein 20 copy A

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Gene Aliases: 9830109N13Rik; AI326939; NOL1; NOL1R; NSUN5; NSUN5A; p120; p120(NOL1); RGD1309268; WBSCR20; WBSCR20A

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UniProt ID: (Human) Q96P11, (Mouse) Q8K4F6

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Entrez Gene ID: (Human) 55695, (Mouse) 100609, (Rat) 288595

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Function(s)
RNA binding methyltransferase activity RNA methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity transferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity poly(A) RNA binding P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity
Process(es)
rRNA processing biological_process methylation RNA methylation oligodendrocyte development cerebral cortex development corpus callosum development regulation of myelination positive regulation of translation cognition rRNA base methylation
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