Peptide sequence: VFSLAMKGDM NLSIVMTTCS TFCALGMMPL LLYIYSRGIY DGDLKDKVPY
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).
Protein Aliases: Cell growth-inhibiting gene 29 protein; growth-inhibiting protein 29; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Na/taurocholate cotransporting polypeptide; Sodium/bile acid cotransporter; sodium/tauro; sodium/taurocholate cotransporter; Sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1; Solute carrier family 10 member 1
Gene Aliases: GIG29; NTCP; SLC10A1
UniProt ID: (Human) Q14973
Entrez Gene ID: (Human) 6554
Molecular Function: primary active transporter