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NTE Polyclonal Antibody detects endogenous levels of NTE protein.
This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Neuropathy target esterase; patatin-like phospholipase domain containing 6; Patatin-like phospholipase domain-containing protein 6; Swiss cheese; Swiss-cheese
Gene Aliases: AI661849; BNHS; iPLA2delta; LNMS; MSws; NTE; NTEMND; OMCS; PNPLA6; RGD1564611; SPG39; sws
UniProt ID: (Human) Q8IY17, (Mouse) Q3TRM4
Entrez Gene ID: (Human) 10908, (Mouse) 50767, (Rat) 360753
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