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Invitrogen
NTHL1 Polyclonal Antibody
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Product Details
PA1-16506
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide derived from human NTH1, conjugated to KLH.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The target sequence has 93% sequence homology with bovine proteins.
Suggested positive control: Hela whole cell lysate, K562 cell extracts, Hela cell extracts, K562 whole cell lysate.
Target Information
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; hNTH1; nth endonuclease III-like 1; NTHL 1; OCTS 3; thymine glycol DNA glycosylase/AP lyase
Gene Aliases: FAP3; hNTH1; NTH1; NTHL1; OCTS3
UniProt ID: (Human) P78549, (Mouse) O35980
Entrez Gene ID: (Human) 4913, (Mouse) 18207, (Rat) 29541
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
double-stranded DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
protein binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
DNA N-glycosylase activity
metal ion binding
4 iron, 4 sulfur cluster binding
purine-specific mismatch base pair DNA N-glycosylase activity
DNA binding
catalytic activity
uracil DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
iron-sulfur cluster binding
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
positive regulation of defense response to virus by host
base-excision repair, AP site formation
nucleotide-excision repair, DNA incision, 5'-to lesion
depyrimidination
mitophagy in response to mitochondrial depolarization
xenophagy
DNA repair
base-excision repair
cellular response to DNA damage stimulus
metabolic process
DNA catabolic process, endonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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