NTS is a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.
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Protein Aliases: Large neuromedin N; Neuromedin N; Neurotensin; Neurotensin/neuromedin N; NmN; NmN-125; NN; NT; pro-neurotensin/neuromedin; Tail peptide
Gene Aliases: 5033428E16Rik; NMN-125; NN; NT; NT/N; NTS; NTS1