|Immunohistochemistry (Paraffin) (IHC (P))||4 - 7 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 18 amino acid peptide from 3rd extracellular domain of human NTSR2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Marmoset (89%).
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Levocabastine-sensitive neurotensin receptor; Neurotensin NT2 receptor; Neurotensin receptor; Neurotensin receptor 2; Neurotensin receptor type 2; neurotensin receptor, type 2; NT-R-2; NT2 receptor; NTSR2; type 2
Gene Aliases: NTR2; NTSR2
UniProt ID: (Human) O95665
Entrez Gene ID: (Human) 23620
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