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Invitrogen
NUDT5 Polyclonal Antibody
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Product Details
PA5-54091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NUDT5. Recombinant protein control fragment (Product #RP-92485).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPAVCMDPGL SNCTIHIVTV TINGDDAENA RPKPKPGDGE FVEVISLPKN DLLQRLDALV AEEHLTVDAR VYSYALALKH ANAKPFEVPF LKF
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 90%.
Target Information
Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; Nudix motif 5; nudix-type motif 5; YSA1H
Gene Aliases: HSPC115; NUDIX5; NUDT5; YSA1; YSA1H; YSAH1
UniProt ID: (Human) Q9UKK9, (Rat) Q6AY63
Entrez Gene ID: (Human) 11164, (Rat) 361274
magnesium ion binding
protein binding
nucleotidyltransferase activity
ADP-sugar diphosphatase activity
snoRNA binding
protein homodimerization activity
8-oxo-dGDP phosphatase activity
ADP-ribose diphosphatase activity
m7G(5')pppN diphosphatase activity
nucleoside-diphosphatase activity
pyrophosphatase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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