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Invitrogen
NUP160 Polyclonal Antibody
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Product Details
PA5-101723
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NUP160(Accession Q12769), corresponding to amino acid residues E425-A475.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NUP160.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-160 is part of the hetero-oligomeric complex that also contains NUP107, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP160 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP160 may be an important drug target in HIV treatment. Multiple isoforms of NUP160 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 160 kDa nucleoporin; Gene trap locus 1-13 protein; gene trap locus-13; GTL-13; Nuclear pore complex protein Nup160; nucleoporin 160kD; nucleoporin 160kDa; Nucleoporin Nup160
Gene Aliases: 160kDa; 2810011M03Rik; AA414952; AU020188; Gtl-13; Gtl1-13; Gtl13; KIAA0197; mKIAA0197; NUP120; NUP160
UniProt ID: (Human) Q12769, (Mouse) Q9Z0W3
Entrez Gene ID: (Human) 23279, (Mouse) 59015
mRNA export from nucleus
tRNA export from nucleus
sister chromatid cohesion
mitotic nuclear envelope disassembly
regulation of glucose transport
protein transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
intracellular transport of virus
regulation of cellular response to heat
transport
mRNA transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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