Immunogen sequence: QLLTRNVVFG LGGELFLWDG EDSSFLVVRL RGPSGGGEEP ALSQYQRLLC INPPLFEIYQ VLLSPTQHHV ALIGIKGLMV LELPKRWGKN SEFEGGKSTV NCSTTPVAER FFTSSTSLTL KHAAWYPSEI LDPHVV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.
The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.
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Protein Aliases: 88 kDa nucleoporin; karyoporin; nuclear pore complex protein 88; Nuclear pore complex protein Nup88; nucleoporin 88kDa; Nucleoporin Nup88
Gene Aliases: NUP88
UniProt ID: (Human) Q99567
Entrez Gene ID: (Human) 4927
Molecular Function: transporter