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Product Details
PA5-54518
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NUP88
Conjugate
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2644903
Product Specific Information
Immunogen sequence: QLLTRNVVFG LGGELFLWDG EDSSFLVVRL RGPSGGGEEP ALSQYQRLLC INPPLFEIYQ VLLSPTQHHV ALIGIKGLMV LELPKRWGKN SEFEGGKSTV NCSTTPVAER FFTSSTSLTL KHAAWYPSEI LDPHVV
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.
Target Information
The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 88 kDa nucleoporin; karyoporin; nuclear pore complex protein 88; Nuclear pore complex protein Nup88; nucleoporin 88kDa; Nucleoporin Nup88
Gene Aliases: NUP88
UniProt ID: (Human) Q99567
Entrez Gene ID: (Human) 4927
Molecular Function:
transporter
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
protein export from nucleus
mitotic nuclear division
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
intracellular transport of virus
regulation of cellular response to heat
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