The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 93 kDa nucleoporin; CBP-interacting protein 4; Nuclear pore complex protein Nup93; nucleoporin 93kDa; Nucleoporin Nup93
Gene Aliases: 2410008G02Rik; Cip4; KIAA0095; NIC96; NPHS12; NUP93
Molecular Function: transporter