|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 393-438 of human NVL|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 95 kDa.
Purity is >95% by SDS-PAGE.
Valosin containing protein (VCP), also designated TERA (for transitional endoplasmic reticulum ATPase), is a member of the AAA family of ATPases, which are involved in a variety of cellular activities. VCP is involved in a variety of membrane functions and in the regulation of the cell cycle. VCP associates with ubiquitinated IkB-a as well as with the 26S proteosome, indicating a potential role for VCP in the proteosome-mediated degradation of IkB-a. NVL (nuclear valosin-containing protein-like), also known as NVLp, is an 856 amino acid nuclear protein belonging to the AAA ATPase family. Implicated in ATP-dependent nuclear processes and ribosome synthesis, NVL exists as three alternatively spliced isoforms designated NVL isoform 1 (NVLp.2), NVL isoform 2 (NVLp.1) and NVL isoform 3. Widely expressed, NVL is found at highest levels in pancreas, retina, heart, skeletal muscle and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.