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Search Thermo Fisher Scientific
Immunogen sequence: MSLPSGHTT GHTDQVVQRR ARCWDIYQRR FSSRSEPVNP GMHSSSHQQQ DGDAAMHGAH MDSPVRYTPY TISPYNRKGS FRKQDQTHVN MEREQKPPER RMEGNMPDGT LGSWFKITVP FGIKYNEKWL LNLIQNECSV PFVPVEFHYE NMHASFFVEN ASIAYALKNV SGKIWDEDNE KISIFVNPAG IPHFVHRELK SEKVEQIKLA MNQQCDVSQE ALDIQRLPFY PDMVNRDTKM ASNPRKCMAA SLDVHEENIP TVMSAGEMDK WKGIEPGEKC ADRSPVCTTF SDTSSNINSI LELF (1-303 aa encoded by BC031616)
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.
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Protein Aliases: Nuclear RNA export factor 3; TAP-like protein 3; TAPL-3
Gene Aliases: Gm384; NXF3; TAPL3
UniProt ID: (Human) Q9H4D5
Entrez Gene ID: (Human) 56000, (Mouse) 245610
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