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NXN Polyclonal Antibody

NXN Antibody in Immunocytochemistry (ICC/IF)

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NXN Antibody (16128-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using NXN antibody (Product # 16128-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red).

NXN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NXN Antibody in Immunoprecipitation (IP)

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Product Details

16128-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NXN Fusion Protein Ag9113 (110-435 aa encoded by BC009327)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to NXN.

Immunogen sequence: ADVSLHRNP ATLKLWNKYR ISNIPSLIFL DATTGKVVCR NGLLVIRDDP EGLEFPWGPK PFREVIAGPL LRNNGQSLES SSLEGSHVGV YFSAHWCPPC RSLTRVLVES YRKIKEAGQN FEIIFVSADR SEESFKQYFS EMPWLAVPYT DEARRSRLNR LYGIQGIPTL IMLDPQGEVI TRQGRVEVLN DEDCREFPWH PKPVLELSDS NAAQLNEGPC LVLFVDSEDD GESEAAKQLI QPIAEKIIAK YKAKEEEAPL LFFVAGEDDM TDSLRDYTNL PEAAPLLTIL DMSARAKYVM DVEEITPAIV EAFVNDFLAE KLKPEPI (110-435 aa encoded by BC009327 )

Target Information

This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.

Cell death & disease

Zhang Y,Zuo D,Qiu J,Li K,Niu Y,Yuan Y,Qiu Y,Qiao L,He W,Wang C,Yuan Y,Li B

Thu Aug 04 00:00:00 UTC 2022

Oxidative stress as a candidate mechanism for accelerated neuroectodermal differentiation due to trisomy 21.

Free radical biology & medicine

Prutton KM,Marentette JO,Leifheit BA,Esquer H,LaBarbera DV,Anderson CC,Maclean KN,Roede JR

Wed Jun 01 00:00:00 UTC 2022

Enzymatic Depletion of Mitochondrial Inorganic Polyphosphate (polyP) Increases the Generation of Reactive Oxygen Species (ROS) and the Activity of the Pentose Phosphate Pathway (PPP) in Mammalian Cells.

Antioxidants (Basel, Switzerland)

Hambardikar V,Guitart-Mampel M,Scoma ER,Urquiza P,Nagana GGA,Raftery D,Collins JA,Solesio ME

Thu Mar 31 00:00:00 UTC 2022

Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation.

Antioxidants (Basel, Switzerland)

Holubiec MI,Romero JI,Urbainsky C,Gellert M,Galeano P,Capani F,Lillig CH,Hanschmann EM

Wed Jun 01 00:00:00 UTC 2022

Nucleoredoxin Plays a Key Role in the Maintenance of Retinal Pigmented Epithelium Differentiation.

Antioxidants (Basel, Switzerland)

Holubiec MI,Romero JI,Urbainsky C,Gellert M,Galeano P,Capani F,Lillig CH,Hanschmann EM

Wed Jun 01 00:00:00 UTC 2022

Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells.

Oxidative medicine and cellular longevity

Urbainsky C,Nölker R,Imber M,Lübken A,Mostertz J,Hochgräfe F,Godoy JR,Hanschmann EM,Lillig CH

Tue Jan 22 00:00:00 UTC 2019

Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells.

Oxidative medicine and cellular longevity

Urbainsky C,Nölker R,Imber M,Lübken A,Mostertz J,Hochgräfe F,Godoy JR,Hanschmann EM,Lillig CH

Tue Jan 22 00:00:00 UTC 2019

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

Science signaling

Hamanaka RB,Glasauer A,Hoover P,Yang S,Blatt H,Mullen AR,Getsios S,Gottardi CJ,DeBerardinis RJ,Lavker RM,Chandel NS

Tue Feb 05 00:00:00 UTC 2013

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development.

Science signaling

Hamanaka RB,Glasauer A,Hoover P,Yang S,Blatt H,Mullen AR,Getsios S,Gottardi CJ,DeBerardinis RJ,Lavker RM,Chandel NS

Tue Feb 05 00:00:00 UTC 2013

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kajla S,Mondol AS,Nagasawa A,Zhang Y,Kato M,Matsuno K,Yabe-Nishimura C,Kamata T

Tue May 01 00:00:00 UTC 2012

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kajla S,Mondol AS,Nagasawa A,Zhang Y,Kato M,Matsuno K,Yabe-Nishimura C,Kamata T

Tue May 01 00:00:00 UTC 2012

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kajla S,Mondol AS,Nagasawa A,Zhang Y,Kato M,Matsuno K,Yabe-Nishimura C,Kamata T

Tue May 01 00:00:00 UTC 2012

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kajla S,Mondol AS,Nagasawa A,Zhang Y,Kato M,Matsuno K,Yabe-Nishimura C,Kamata T

Tue May 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Nucleoredoxin; nucleoredoxin 1; Protein Red-1

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Gene Aliases: Gn25; l11Jus13; NRX; NXN; TRG-4

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UniProt ID: (Human) Q7L4C6, (Mouse) P97346

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Entrez Gene ID: (Human) 64359, (Mouse) 18230, (Rat) 360577

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Function(s)

thioredoxin-disulfide reductase activity protein-disulfide reductase activity protein binding oxidoreductase activity oxidoreductase

Process(es)

Wnt signaling pathway cell differentiation negative regulation of Wnt signaling pathway negative regulation of protein ubiquitination cell redox homeostasis oxidation-reduction process cardiovascular system development cellular oxidant detoxification multicellular organism development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NXN Polyclonal Antibody

NXN Antibody (16128-1-AP) in ICC/IF

Product Details

16128-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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