Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.
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Protein Aliases: hNaDC3; mNaDC3; Na(+)/dicarboxylate cotransporter 3; NaDC-3; sodium-dependent high affinity dicarboxylate transporter 3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3
Gene Aliases: NaDC-3; NADC3; SDCT2; SLC13A3