Immunogen sequence: VRVQVLPEVR GQLGGTVELP CHLLPPVPGL YISLVTWQRP DAPANHQNVA AFHPKMGPSF PSPKPGSERL SFVSAKQSTG QDTEAELQDA TLALHGLTVE DEGNYTCEFA TFPKGSVRGM TWLR
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; Nectin cell adhesion molecule 2; Nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2; PRR2; PVRL2; PVRR2
Gene Aliases: CD112; HVEB; NECTIN2; PRR2; PVRL2; PVRR2
UniProt ID: (Human) Q92692
Entrez Gene ID: (Human) 5819