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Invitrogen
Nectin 4 Polyclonal Antibody
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FIGURE: 1 / 2
Nectin 4 Antibody (PA5-47365) in IHC (P)
Immunohistochemical analysis of Nectin 4 in immersion fixed paraffin-embedded sections of human placenta. Samples were incubated in Nectin 4 polyclonal antibody (Product # PA5-47365) using a dilution of 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained with the Anti-Goat HRP... View More
Product Details
PA5-47365
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Nectin-4 Gly27-Val351
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs and Western blots, approximately 75% cross-reactivity with recombinant mouse Nectin-4 is observed and less than 2% cross-reactivity with recombinant human (rh) Nectin-1, rhNectin-2 and rhNectin-3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Nectin 4 (PVRL4) is a gene located on chromosome 1q23.3 that encodes a member of the nectin family of cellular adhesion molecules. These proteins are primarily involved in forming adherens junctions between epithelial cells, contributing to tissue integrity and maintenance in various tissues, including the skin, lungs, and mammary glands. Nectin 4 is highly expressed during embryonic development and is crucial for processes like tissue morphogenesis and repair. It acts as a ligand for the poliovirus receptor-related family and participates in cell signaling pathways that influence cell proliferation and survival. In the context of cancer, Nectin 4 is often upregulated, particularly in breast, ovarian, and lung cancers, where its expression is associated with tumor progression, metastasis, and poor prognosis. This makes Nectin 4 a potential target for therapeutic interventions and a candidate biomarker for cancer diagnosis and monitoring.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ig superfamily receptor LNIR; nectin 4; Nectin cell adhesion molecule 4; Nectin-4; poliovirus receptor-related 4; Poliovirus receptor-related protein 4
Gene Aliases: EDSS1; LNIR; nectin-4; NECTIN4; PRR4; PVRL4
UniProt ID: (Human) Q96NY8
Entrez Gene ID: (Human) 81607
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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