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Invitrogen
Neogenin Polyclonal Antibody
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FIGURE: 1 / 3
Neogenin Antibody (PA5-115639) in ICC/IF
Immunocytochemistry analysis of Neogenin in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115639). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
Product Details
PA5-115639
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NEO1(Accession Q92859), corresponding to amino acid residues Y822-I872.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Neogenin.
Target Information
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsT17534; Immunoglobulin superfamily DCC subclass member 2; NEO; Neogenin; neogenin homolog 1; NGNDKFZp547A066
Gene Aliases: 2610028H22Rik; AI327052; D930014N22Rik; IGDCC2; NEO1; NGN; NTN1R2
UniProt ID: (Human) Q92859, (Mouse) P97798
Entrez Gene ID: (Human) 4756, (Rat) 81735, (Mouse) 18007
regulation of transcription, DNA-templated
cell adhesion
myoblast fusion
positive regulation of BMP signaling pathway
negative regulation of protein secretion
iron ion homeostasis
neuron migration
cellular iron ion homeostasis
axon guidance
protein secretion
regulation of axon regeneration
negative regulation of axon regeneration
multicellular organismal iron ion homeostasis
cell-cell adhesion
trans-synaptic signaling, modulating synaptic transmission
negative regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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