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Product Details
22912-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Nephrin fusion protein Ag18994
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PARGEFHLHI EACDLSDDAE YECQVGRSEM GPELVSPRVI LSILVPPKLL LLTPEAGTMV TWVAGQEYVV NCVSGDAKPA PDITILLSGQ TISDISANVN EGSQQKLFTV EATARVTPRS SDNRQLLVCE ASSPALEAPI KASFTVNVLF PPGPPVIEWP GLDEGHVRAG QSLELPCVAR GGNPLATLQW LKNGQPVSTA WGTEHTQAVA RSVLVMTVRP EDHGAQLSCE AHNSVSAGTQ EHGITLQVTF PPSAIIILGS ASQTENKNVT LSCVSKSSRP RVLLRW
Target Information
Primary steroid resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss. Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin, a recently identified protein is a member of a group of podocyte proteins that constitute major component of the slit diaphragm especially in the foot process. Nephrin, a cell adhesion molecule, may play a crucial role in maintaining the glomerular filtration barrier. Recent studies have suggested that mutations in the gene for Nephrin reportedly lead to congenital nephrosis. Three novel podocyte proteins, Podocin, Nephrin and alpha Actinin 4 have been identified in congenital and experimental models of proteinuria. The role of Nephrin in anti apoptotic activity in podocyte slit diaphragm is believed to be associated with vascular endothelial derived growth factors VEGF signaling. Nephrin seems to play a role in the development or function of the kidney glomerular filtration barrier and it may anchor the podocyte slit diaphragm to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nephrin; nephrin 1; nephrosis 1 homolog, nephrin; nephrosis 1, congenital, Finnish type (nephrin); NPHS1 nephrin; Renal glomerulus-specific cell adhesion receptor
Gene Aliases: CNF; nephrin; NephrinB; NPHN; NPHS1
UniProt ID: (Human) O60500, (Rat) Q9R044, (Mouse) Q9QZS7
Entrez Gene ID: (Human) 4868, (Rat) 64563, (Mouse) 54631
MAPK cascade
glomerular filtration
cell adhesion
JNK cascade
skeletal muscle tissue development
myoblast fusion
positive regulation of actin filament polymerization
glomerular basement membrane development
regulation of excretion
glomerular visceral epithelial cell development
multicellular organism development
muscle organ development
excretion
protein localization to synapse
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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