NUCB2 was initially identified as calcium-binding protein EF hand motif-containing protein that could bind with Necdin, a growth suppressor expressed primarily in postmitotic neurons. NUC2 is a secreted protein that is cleaved into three major peptide products, Nesfatin-1, Nesfatin-2, and Nesfatin-3, of which Nesfatin-1 has been found to cause the suppression of food intake in a leptin-independent manner. Other studies have suggested that NUCB2/Nesfatin-1 may also play roles in energy homeostasis and closely related neuroendocrine functions.
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Protein Aliases: DNA-binding protein NEFA; Epididymis secretory protein Li 109; Gastric cancer antigen Zg4; nesfatin 1; Nesfatin-1; Nucleobindin-2; Nucleobindin-2/Nesfatin-1; nucleobinding 2; prepronefastin; Prepronesfatin
Gene Aliases: AI607786; Calnuc; HEL-S-109; NEFA; Nesfatin-1; NUCB2; p54
Molecular Function: calmodulin-related