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Immunogen sequence: NVLNDAYENL TRYKEAVTRA VESITSLEAI IIPYRVDVGN PEESLEMPLR KQEELESTVA RIQDLTEKLG MISSPEAKLQ LQYTLQELVS KNSAMKEAFK AQETEAE
Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 29%.
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KASH domain-containing protein 2; KASH2; MGC96690; nesprin 2; Nesprin-2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; polytrophin; Protein NUANCE; spectrin repeat containing, nuclear envelope 2; Synaptic nuclear envelope protein 2; synaptic nuclei expressed gene 2; Syne-2
Gene Aliases: EDMD5; KIAA1011; Nesp2; Nesprin-2; NUA; NUANCE; SYNE-2; SYNE2; TROPH
UniProt ID: (Human) Q8WXH0
Entrez Gene ID: (Human) 23224
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