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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
0.1 µg/mL | - |
Immunocytochemistry (ICC/IF) |
5-15 µg/mL | - |
ChIP assay (ChIP) |
2.5 µg/10^6 cells | - |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Published species |
Rat |
Host/Isotype |
Goat / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
E. coli-derived recombinant human NeuroD1 Ser154-Asp356 |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 5% trehalose |
Contains |
No Preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2607915 |
Approximately 5% cross-reactivity with recombinant human NeuroD2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It has been demonstrated to bind to the insulin gene E-box. Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. Defects in NEUROD1 are a cause of maturity onset diabetes of the young type VI (MODY6). MODY6 is a form of non-insulin-dependent diabetes mellitus characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: basic helix-loop-helix transcription factor; beta-cell E-box transactivator 2; Beta-cell E-box transcriptional activator 2; Beta2; BHF1; bHLHa3; Class A basic helix-loop-helix protein 3; neuro d1; NeuroD; NeuroD1; Neurogenic differentiation factor 1; neurogenic helix-loop-helix protein NEUROD
Gene Aliases: BETA2; BHF-1; BHLHA3; MODY6; NEUROD; NEUROD1
UniProt ID: (Human) Q13562, (Mouse) Q60867
Entrez Gene ID: (Human) 4760, (Mouse) 18012
Molecular Function:
basic helix-loop-helix transcription factor
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