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Proteintech
Neurocan Polyclonal Antibody
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Product Details
27087-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Neurocan Fusion Protein Ag25821
Conjugate
Form
Liquid
Concentration
567 µg/mL
Amount
85.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Neurocan is a gene encoding a large chondroitin sulfate proteoglycan, predominantly expressed in the central nervous system. Located on chromosome 19 in humans, neurocan is part of the lectican family of proteoglycans, integral to the extracellular matrix where they modulate neuronal cell adhesion and migration. This proteoglycan is essential in the formation of the neural network during development and in maintaining the plasticity of the extracellular matrix in adult brains. Neurocan undergoes proteolytic processing, resulting in various fragments that influence neuronal growth and synapse stabilization. Altered neurocan expression has been linked to several neurological conditions such as schizophrenia, bipolar disorder, and Alzheimer's disease, likely due to its role in synaptic function and integrity of the neural matrix. Understanding neurocan's exact roles in neurological health and disease could illuminate pathways for potential therapeutic interventions targeting matrix remodeling and neuronal connectivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aggrecan proteoglycan family; Chondroitin sulfate proteoglycan 3; chondroitin sulfate proteoglycan 3 (neurocan); Neurocan core protein; neurocan proteoglycan; unnamed protein product
Gene Aliases: CSPG3; NCAN; NEUR
UniProt ID: (Human) O14594
Entrez Gene ID: (Human) 1463
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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