The synthetic peptide sequence is HENTWIGLNDRIVERDFQWTDNTGLQFENWRENQPDNFFA
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
The lecticans are a family of chondroitin proteoglycans, including aggrecan, versican, neurocan and brevican, that contain a C-type lectin domain. Neurocan is a glycoprotein synthesized primarily by neurons, and its expression levels are highest during embryonic brain development and during the early postnatal period. Neurocan is a component of the extracellular matrix in the central nervous system that can bind to various other CNS matrix components, such as heparin, Tenascin-R, HB-GAM and NCAM, suggesting that it plays a role in axon guidance and neurite growth. Neurocan is a 1,257 amino acid, precursor protein in embryonic and neonatal rats that is proteolytically proc-essed in the adult CNS into an N-terminal fragment, which localizes to the cytoplasm of glial cells. Neurocan expression (including the re-expression of the neonatal isoform) increases significantly in adults in the glial scar resulting from cortical injury.
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Protein Aliases: 245 kDa early postnatal core glycoprotein; Chondroitin sulfate proteoglycan 3; chondroitin sulfate proteoglycan 3 (neurocan); chondroitin sulfate proteoglycan 3, related sequence; CSPG3; NCAN; NEUR; Neurocan core protein; neurocan proteoglycan; TGFbeta-induced transcript, brain
Gene Aliases: C230035B04; CSPG3; Cspg3-rs; NCAN; NEUR; Tgfbit